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Grimm conjectures that if 
, 
, ..., 
 are all Composite Numbers, then there
are distinct Primes 
 such that 
 for 
.
References
Guy, R. K.  ``Grimm's Conjecture.''  §B32 in 
  Unsolved Problems in Number Theory, 2nd ed.  New York: Springer-Verlag, p. 86, 1994.